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What is meclizine?

Meclizine is an antihistamine that reduces the effects of natural chemical histamine in the body.

Meclizine is used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness. It is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused by disease that affects your inner ear.

Meclizine may also be used for purposes not listed in this medication guide.

Important information about meclizine

You should not take this medication if you are allergic to meclizine.

Before you take meclizine, tell your doctor if you have liver or kidney disease, asthma, glaucoma, an enlarged prostate, or urination problems.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of meclizine.

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by meclizine.

Before taking meclizine

You should not use meclizine if you are allergic to it.

To make sure meclizine is safe for you, tell your doctor if you have any of these conditions:

  • liver disease;

  • kidney disease;

  • asthma;

  • glaucoma;

  • enlarged prostate; or

  • urination problems.

FDA pregnancy category B. Meclizine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether meclizine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

This medicine should not be given to a child younger than 12 years old.

How should I take meclizine?

Use meclizine exactly as directed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

The chewable tablet must be chewed before you swallow it.

To prevent motion sickness, take meclizine about 1 hour before you travel or engage in activity that causes motion sickness. You may take a dose once every 24 hours while you are traveling, to further prevent motion sickness.

To treat vertigo, you may need to take meclizine several times daily. Follow your doctor's instructions.

This medication can affect the results of allergy skin tests. Tell any doctor who treats you that you are using meclizine.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Since meclizine is sometimes taken only when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking meclizine?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of meclizine.

Meclizine side effects

Get emergency medical help if you have any of these signs of an allergic reaction to meclizine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common meclizine side effects may include:

  • headache;

  • vomiting;

  • dry mouth;

  • tired feeling; or

  • drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Meclizine Dosing Information

Usual Adult Dose for Nausea/Vomiting:

25 to 50 mg orally once a day as needed.

Usual Adult Dose for Vertigo:

25 mg orally 1 to 4 times a day or 50 mg orally twice a day.

Usual Adult Dose for Motion Sickness:

25 to 50 mg orally once a day as needed. Meclizine should be administered one hour prior to travel and continued for the duration of exposure.

Do not exceed 50 mg in 24 hours.

Usual Pediatric Dose for Nausea/Vomiting:

> 12 years: 25 to 50 mg orally once a day as needed.

Usual Pediatric Dose for Vertigo:

> 12 years: 25 mg orally 1 to 4 times a day or 50 mg orally twice a day.

Usual Pediatric Dose for Motion Sickness:

> 12 years: 25 to 50 mg orally once a day as needed. Meclizine should be administered one hour prior to travel and continued for the duration of exposure.

Do not exceed 50 mg in 24 hours.

What other drugs will affect meclizine?

Taking meclizine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking meclizine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine, especially:

  • cinacalcet;

  • quinidine;

  • terbinafine; or

  • the antidepressants bupropion, duloxetine, fluoxetine, paroxetine, or sertraline.

Other drugs may interact with meclizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

For the Consumer

Applies to meclizine: oral capsule, oral tablet, oral tablet chewable

Along with its needed effects, meclizine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking meclizine:

Incidence not known
  • Cough
  • difficulty swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness

Some side effects of meclizine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
  • Blurred vision
Incidence not known
  • Dry mouth
  • headache

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Applies to meclizine: compounding powder, oral tablet, oral tablet chewable

Nervous system

Nervous system (CNS) side effects have included headache, drowsiness and sedation. Motor skills may be impaired.

With continued therapy, sedation due to meclizine diminishes.

An elderly woman suffered from memory loss, disorientation, paranoia, and agitation during treatment with meclizine over approximately 3 years. These symptoms returned on rechallenge.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, dry mouth, and constipation.

Ocular

Ocular side effects have included blurred vision, diplopia, and dry eyes.

Genitourinary

Genitourinary side effects have included urinary retention and dysuria.

Hypersensitivity

Anaphylactoid reactions have been reported.

Other

Fatigue has been reported.